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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A team from I2BC has studied the regulation of oxygen reduction to superoxide at photosystem I (PSI) in several redox mutants of the plant A.thaliana, grown during different photoperiods. The results enable to propose a new model of PSI-specific redox regulation, capable of rapid adaptation according to light conditions
A team from GHU Paris and SHFJ has used brain MRI to study the integrity of the locus coeruleus and nucleus basalis of Meynert in patients with early-onset Alzheimer's disease (AD), age-related TDP-43 encephalopathy (LATE) and fronto-temporal dementia (FTD). Both structures are altered in early AD, LATE and probably FTD, making these neuromodulatory areas potential therapeutic targets
Three DES and DRF laboratories have developed an innovative Machine Learning algorithm to improve the reconstruction of PET images acquired as part of the ClearMind project, a technology based on the detection of gamma photons by a monolithic lead tungstate crystal detector. A step towards more accurate PET imaging
A study conducted by NeuroSpin researchers reveals abnormalities in functional brain connectivity in the sub-nucleus region of the amygdala (emotion center), in patients with bipolar disorder. These anomalies, which depend on whether the patient is depressed or manic, are potential biomarkers of interest.
A BioMaps team has used PET imaging to monitor glucose metabolism as a marker of the cerebral impact of smoking cessation, as well as the effects of a promising drug-candidate for the treatment of such cessation. By revealing the restoration of normal activity in the brain area associated with craving, these results offer hope for smoking cessation in humans
An I2BC team has revealed the structure of the C-terminal transmembrane region of the SARS-CoV-2 protein nsp3, essential for virus replication. This region self-assembles into hexamers that form molecular pores on the surface of double-membrane vesicles, the sites of viral genome replication. Nsp3 therefore appears to be a promising therapeutic target.
A NeuroSpin team analyzed the MEG response of volunteers exposed to auditory sequences organized in network. Finding that participants' brain activity was sensitive to the structure of the network, it concluded that learning the structure of auditory sequences involves a single cognitive process, associative learning.
Several NeuroSpin researchers have taken part in the Individual Brain Charting (IBC) project, aimed at creating a precise map of the cognitive functions of the human brain. In this third phase, they are using the Fast Shared Response Model to analyze large-scale fMRI data and model responses to natural stimuli involving the visual, auditory and language systems.
As a stakeholder in the NOMATEN Centre of Excellence for innovative multifunctional materials, the CEA-Joliot Institute supports its development by regularly organizing training sessions for its staff. The latest examples.
Using a range of spectroscopic techniques, researchers at I2BC in collaboration with ICMMO have elucidated the catalytic cycle of a bio-inspired iron porphyrin catalyst, which could form the basis of economically viable solutions for the conversion and recovery of CO2.
SCBM researchers have designed nanometric micelles that can be activated by light and constructed by self-assembly of amphiphiles derived from ferrocene, which carries a hidden therapeutic activity in the absence of activation.
A SIMoS team has made a significant breakthrough in understanding the cellular immune response to factor VIII, a protein essential for blood coagulation, by demonstrating for the first time the existence of human FVIII-specific regulatory T cells in the blood of healthy donors.
Researchers at BioMaps have developed a "re-bridging agent" for the radiolabelling of biomolecules containing disulphide bridges. Their strategy has enabled several molecules of therapeutic interest to be labelled with fluorine-18, copper-64 and zirconium-89.
Researchers from the AMIG team (I2BC department), in collaboration with the IRB (Switzerland), have modeled the interaction between HROB and the helicases MCM8-MCM9, some mutations of which predispose individuals to infertility or cancer. They demonstrate that HROB promotes the catalytic activity of the MCM8-MCM9 complex but does not play a role in its recruitment or stability.
The CEA is revealing a series of in vivo human brain images acquired with the Iseult MRI machine and its unmatched 11.7 teslas magnetic field strength. This success is the fruit of more than 20 years of R&D as part of the Iseult project, with one pillar goal being to design and build the world’s most powerful MRI machine. Its ambition is to study healthy and diseased human brains with an unprecedented resolution, allowing us to discover new details relating to the brain’s anatomy, connections, and activity.
In an article in the New York Times, Stanislas Dehaene (NeuroSpin director) and Mathias Sablé-Meyer (PhD student) discuss recent results obtained in collaboration with the Collège de France, the CNRS and the University of Paris 8 that show that humans have a universal capacity to understand abstract geometric concepts.
September 2021, the 11.7 Tesla MRI of the Iseult project, the most powerful in the world for human imaging, has just unveiled its first images.
CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.
