Team Leader
Louisa BARRÉ
Description
The
Laboratory for Methodological Developments in Positron Emission Tomography (LDM-TEP) is a structure based within the UMR 6301 CNRS-CEA-UCBN «
Imaging and Therapeutical Strategies in Cerebral and Tumoral pathologies » (ISTCT), managed by Myriam Bernaudin and is located at Cyceron, a biomedical imaging platform in Caen (France).
LDM-TEP, managed by
Louisa Barré, is a unique structure whose primary mission is research at the interface between
chemistry and radiochemistry and
biology to exploit and enlarge the scope of
PET imaging. LDM-TEP focuses on the development of radiopharmaceuticals biomarkers for preclinical and clinical research.
| Armored cells equipped with remote controlled synthesis PLCs - @P.Stroppa/CEA |
| Development of the synthesis of marking precursors which will be used later for the development of new radiotracers - @P.Stroppa/CEA
|
 | PET / CT Clinical Camera PET / CT GE RX VCT 64 - © LDM-TEP CEA |
Three undernoted themes
-
Innovative radiochemical approaches that involve positron emitters (sultones strategy, vectorisation of molecules,...) ;
- The development and study of novel radiotracers as potential radiopharmaceutical agents (NR2B NMDA receptors, opiates receptors, lymphoma or apoptosis) ;
- The introduction of clinical radiotracers for the benefit of the varied users within the GIP Cyceron (FLT, FMISO, AV-45,...).
For each of these three themes and, above all the latter, our team masters the disciplines of organic and analytical chemistry as well as radiochemistry and radiopharmacy. Our varied competences in the above fields allows (after automation), the transfer of radiopharmaceuticals to internal and external structures. The valorisation and application of our specificities in these areas allows the rapid clinical evaluation of promising radiopharmaceuticals.