Assessment of the status of onchocerciasis worms with DRS: Proposal of a standardized measurement protocol
| Auteurs | Planat-Chrétien A., Berger M., Wanji S., Boussinesq M., Pedrique B., Dinten J.-M. |
| Year | 2017-0013 |
| Source-Title | Optics InfoBase Conference Papers |
| Affiliations | CEA-LETI, Minatec Campus, 17 rue des Martyrs, Grenoble Cedex 9, France, REFOTDE, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon, Institut de Recherche pour le Développement, UMI 233 TransVIHMI, 911 avenue Agropolis, BP 64501, Montpellier cedex 5, France, Drugs for Neglected Diseases initiative (DNDi), Chemin Louis-Dunant 15, Geneva, Switzerland |
| Abstract | In the present work, we show the capacity of spatially resolved Diffuse Reflectance Spectroscopy (DRS) to identify live and dead worms in ex vivo Onchocerca ochengi nodules. It demonstrates the potential of DRS to diagnose the worm state and to monitor the effect of a drug on macrofilariae. These results have been obtained in constrained conditions, leading to the proposal of a rigorous acquisition and analysis protocol that may contribute to standardized measures in diffuse optics. © 2017 SPIE-OSA. |
| Author-Keywords | |
| Index-Keywords | Constrained conditions, Diffuse reflectance spectroscopy, Ex-vivo, Spatially resolved, Standardized measurement |
| ISSN | 16057422 |
| Lien vers article | Link |