On the use of polymeric additives to promote plasma separation from whole blood in open microchannels
| Auteurs | Lee E., Berthier J., Laurent P., Navarro F., Cubizolles M. |
| Year | 2017-0058 |
| Source-Title | Advanced Materials - TechConnect Briefs 2017 |
| Affiliations | Department of Chemical Engineering, MIT, Cambridge, MA, United States, University Grenoble Alpes, Grenoble, France, Department of Biotechnology, CEA, LETI, MINATEC Campus, Grenoble, France |
| Abstract | Polymers additives in whole blood are known to modify blood physical properties. For example, IgG, IgM and Dextran molecules accelerate the aggregation of re-suspended RBCs in Ringer solutions. In this work, we first investigate the effect of polymers such as Dextran, PEG (polyethylene glycol) and PVP (polyvinyl propylene) on the aggregation of RBCs directly in whole blood. We find that Dextran does not promote the aggregation in whole blood (in contrast to re-suspended RBCs in Ringer solutions), which PEG and PVP achieve. In a second step, we make use of the aggregative properties of PEG and PVP to boost plasma separation from whole blood in open microftuidic channels. The approach is based on an enhanced sedimentation rate of RBCs aggregated by the polymers. |
| Author-Keywords | Dextran, PEG, Point-of-Care (POC), PVP, RBC aggregation, Whole blood |
| Index-Keywords | Blood, Dextran, Polyethylene glycols, Surface measurement, Dextran molecules, Open microchannel, Plasma separation, Point of care, Polymeric additives, Ringer solutions, Sedimentation rates, Whole blood, Polymers |
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