This paper introduces a plug-and-play on-chip asynchronous communication network aimed at the dynamic reconfiguration of a low-power adaptive circuit such as an internet of things (IoT) system. By using a separate communication network, we can address both digital and analog blocks at a lower configuration cost, increasing the overall system power efficiency. As reconfiguration only occurs according to specific events and has to be automatically in stand-by most of the time, our design is fully asynchronous using handshake protocols. The paper presents the circuit’s architecture, performance results, and an example of the reconfiguration of frequency locked loops (FLL) to validate our work. We obtain an overall energy per bit of 0.07 pJ/bit for one stage, in a 28 nm Fully Depleted Silicon On Insulator (FDSOI) technology at 0.6 V and a 1.1 ns/bit latency per stage. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.