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Fabrication of monodisperse magnetic nanoparticles released in solution using a block copolymer template

Publié le 29 mars 2018
Fabrication of monodisperse magnetic nanoparticles released in solution using a block copolymer template
Auteurs
Morcrette M., Ortiz G., Tallegas S., Joisten H., Tiron R., Baron T., Hou Y., Lequien S., Bsiesy A., Dieny B.
Year2017-0322
Source-TitleJournal of Physics D: Applied Physics
Affiliations
Univ. Grenoble Alpes, CEA, CNRS, Grenoble Institute of Engineering, Univ. Grenoble, INAC, SPINTEC, Grenoble, France, Univ. Grenoble Alpes, CNRS, LTM, Grenoble, France, Univ. Grenoble Alpes, CEA, LETI, DCOS, LCMC, Grenoble, France, Univ. Grenoble Alpes, CEA, INAC, MEM, Grenoble, France
Abstract
This paper describes a fabrication process of monodisperse magnetic nanoparticles released in solution, based on combined 'top-down' and 'bottom-up' approaches. The process involves the use of a self-assembled PS-PMMA block copolymer formed on a sacrificial layer. Such an approach was so far mostly explored for the preparation of patterned magnetic media for ultrahigh density magnetic storage. It is here extended to the preparation of released monodisperse nanoparticles for biomedical applications. A special sacrificial layer had to be developed compatible with the copolymer self-organization. The resulting nanoparticles exhibit very narrow size dispersion (?7%) and can be good candidates as contrast agents for medical imaging i.e. magnetic resonance imaging or magnetic particle imaging. The approach provides a great freedom in the choice of the particles shapes and compositions. In particular, they can be made of biocompatible magnetic material. © 2017 IOP Publishing Ltd.
Author-Keywords
block copolymer, magnetic nanoparticles, medical imaging, size dispersion
Index-Keywords
Biocompatibility, Biological materials, Block copolymers, Dispersions, Magnetic materials, Magnetic resonance imaging, Magnetic storage, Magnetism, Medical applications, Medical imaging, Nanoparticles, Biomedical applications, Block copolymer templates, Fabrication process, Magnetic nano-particles, Magnetic particle imaging, Monodisperse nanoparticles, Patterned magnetic media, Size dispersion, Nanomagnetics
ISSN223727
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