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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Researchers at SIMoS (DMTS) describe the synthesis, engineering and evaluation of the properties of the B subunit of bacterial Shiga toxin (STxB), administered mucosally, as a vaccine tool. Their results confirm the value of using a synthetic STxB in an anti-tumor and anti-infectious vaccination strategy.
SHFJ researchers have validated the use of a new biomarker, the nonlinear shear modulus, to measure the elasticity of biological tissues, by comparing results obtained using echography with those obtained using MRI imaging and digital simulation. This biomarker is of particular interest for the diagnosis of certain breast cancers.
A study carried out by the Biomaps laboratory (SHFJ) provides initial evidence to support the use of PET scans using the [18F] DPA-714 radiotracer as an additional tool for the pre-surgical localisation of epileptogenic zones in patients with drug-resistant epilepsy.
SIMoS researchers have shown that by combining two approaches, in silico and in vitro, it is possible to select therapeutic antibodies whose functionality is preserved while reducing the risk of them inducing an undesirable immune response.
I2BC researchers show that the Rif1 protein restrains the replication program and the recruitment of replication initiation factors during early embryonic divisions in X laevis. A step towards elucidating the molecular mechanisms involved in diseases resulting from Rif1 mutations in humans
I2BC researchers identify drought-resistant mutants of the model plant A. thaliana. These mutants are no longer able to carry out the state transition, a process that enables plants to adjust the absorption of light by their two photosystems in an optimal way. They could constitute a way of improving crop resistance to drought.
In an article published in the journal Nucleic Acids Research, scientists from the I2BC, lPBS and the Institute for Structural and Chemical Biology (University of Leicester, UK) demonstrate how phytic acid, a product of cellular metabolism, stabilises the assembly of a complex enabling the repair of DNA breaks in humans.
Researchers at SPI are proposing an innovative multiplexing method for rapid identification of several microbial isolates in a single mass spectrometry analysis. This approach opens up prospects for the large-scale identification of microorganisms resulting from culturomics programs.
Researchers from SCBM (DMTS) and SB2SM (I2BC) describe a novel and optimized approach to the total photoreduction of 13C-labelled CO2 to carbon monoxide (CO), and the immediate reuse of the latter for the synthesis of high value-added compounds. A step towards a radiochemistry of carbon isotopes potentially useful in human health.
In a review article published in Nature Neuroscience, researchers, including Florent Meyniel from UNICOG (NeuroSpin), show that the two dominant approaches to the neural representation of uncertainty are complementary and would benefit from being used synergistically.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.