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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
The UMR1184S Autoimmune Diseases Team (IDMIT CEA-Jacobl) has published an article in Arthritis & Rheumatology confirming a direct pathogenic role for salivary epithelial cells in primary Sjögren syndrome.
In an article published in Oncogene, researchers from LRTS and LRIG (IRCM/CEA-Jacob) have shown that an increase in the expression of cellular prion protein driven by the ATM/TAK1/JUNK signaling pathway contributes to solid tumor radioresistance.
In an unprecedented work published in Brain, researchers from LMN (MIRCen/CEA-Jacob) showed that these abnormal tau proteins migrate from neurons to astrocytes, another type of cell within the brain, and remain toxic in the astrocytes as well.
In a partnership with IDMIT (CEA-Jacob) and Institut Pasteur, the Epigenetic and Environment Laboratory (LEE; CNRGH/CEA-Jacob) carried out two studies to evaluate DNA methylation in non-human primate models of immunodeficiency virus infections.
Glioblastomas are highly aggressive brain tumors with a very poor prognosis. Even with aggressive treatment, recurrence is nearly systematic. Researchers from IRCM (CEA-Jacob) have decrypted molecular mechanisms that enable treatment resistance and escape for a subpopulation of cells.
Researchers from MIRCen (CEA-Jacob) have shown that exposure to alpha-synuclein aggregates may affect dopaminergic neuron survival in Parkinson's disease by reducing astrocyte support for them.
In an international collaboration, a team from MIRCen (CEA-Jacob) studied the properties of toxic alpha-synuclein aggregates in fixed brain samples from patients, depending on their tissue origin and the type of synucleinopathy developed.
A new international study, published in Cell, co-leaded by IDMIT (CEA-Jacob) and the Department of Medical Microbiology of the University of Amsterdam, presents the results of preclinical trials of a new protein vaccine candidate against Covid-19.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.