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The François Jacob Institute of Biology brings together five departments and three services
The last two years in scientific news
A team of researchers from Inrae, Orleans University, the University of Oregon (USA), CEA-Jacob and IRD studied the role of epigenetics in drought tolerance in poplars. Their results, published in New Phytologist, suggest that epigenetic changes during droughts affect the genes involved in the tree's hormonal response to water deficits and may result in genetic mutations.
A team comprising iRCM (CEA-Jacob) and NeuroSpin (CEA-Joliot) researchers analyzed the consequences of irradiation on brain development and neurogenesis in a preclinical model. That work, published in Radiation Research, lays a path for the use of diffusion imaging for the early detection of neurological abnormalities resulting from different types of stress.
In a study published in Cell Systems, the SysFate laboratory (UMR8030/Genoscope/CEA-Jacob) presented MULTILAYER, an algorithm that provides digital functional maps of biological organs or tissues.
The mechanisms that control the stability of telomeres, structures located at the ends of chromosomes, remain largely mysterious. One of them however has been decrypted by researchers from IRCM (CEA-Jacob) and I2BC (CEA-Joliot) in a work carried out in yeasts. Their results, published in Nature Communications, could help identify new therapeutic targets in human cancers.
In a study published in Molecular Therapy, LCSAT (IDMIT, CEA-Jacob) researchers present a novel, optimized, lentiviral gene therapy for β-thalassemia.
In a study published in the Journal of Clinical Investigation, researchers from IDMIT's LCSAT lab (CEA-Jacob) evaluated PPAR-γ ligands in the development of myelofibrosis.
In a study published in JBC, researchers from MIRCen (CEA-Jacob) deployed a range of techniques to map the surfaces of various pathogenic alpha-synuclein aggregates, establishing thus "fingerprints" specific to each aggregate.
The microbial composition and metabolome of the intestinal microbiota of an animal model for COVID-19 were altered over the disease course and remained so after the resolution of lung infection. Those results, which will contribute were brought to light by the Institut Pasteur in Lille in partnership with IDMIT (CEA-Jacob).
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.