By using a combination of molecular biology, genomics, super-resolution microscopy and cellular biology techniques applied to both in vitro and in vivo models, our projects focus on the understanding and modulation of the cellular responses induced by exposure to oxidizing agents or ionizing radiation. Chemical molecules and metallic nanoparticles modulating the redox state of the cells and inducing DNA instability are under study for their potential as new therapies for the treatment of cancer or neurodegenerative disorders.
ONGOING PROJECTS :
- Molecular mechanisms involved in the assembly of Base Excision Repair complexes in the context of chromatin architecture. Link between repair of oxidative DNA damages and transcription
- Repair of oxidative DNA damage in mitochondria and its role in the maintenance of mitochondrial genome
- Effect of ionizing radiation on mitochondrial network and mitochondrial DNA stability.
- Role of OGG1 in the Epithelial Mesenchymal Transition and in the resistance of tumor cell to radio or chemotherapy
- Identification of novel therapeutical approaches for the treatment of cancer and neurodegenerative diseases based on the use of chemical molecules affecting redox state and genome stability.
- Development of metallic nanoparticles for the optimization of individual radiotherapy: in situ dosimetry and radiosensitization effect. Study of oxidative stress and DNA instability induced by the combined treatment in order to better understand the molecular mechanisms involved.