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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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The participative study on our time perception during the confinement, led by Virginie van Wassenhove (NeuroSpin), provides the first open database, Blursday, which analyzes the nature of the alterations in our relationship to time during physical and social distancing, as we experienced during the Covid-19 pandemic.
By measuring fMRI responses to written words, faces, houses and checkerboards in three groups of children, pre-readers and beginning readers aged 6 and advanced readers aged 9, a team from UNICOG (NeuroSpin) shows that reading acquisition recycles and specializes a pre-existing but plastic visual circuit connected to language areas.
A team from SIMoS, in collaboration with the SCBM (DMTS), has developed an original bioanalytical approach based on the double 14C-3H isotopic labeling of an antibody-drug conjugate, allowing the simultaneous in vivo monitoring of the two components in mouse models as well as their precise quantification in the organs.
A team from NeuroSpin provides evidence that the prefrontal cortex reliably encodes visual stimuli even under conditions that have been shown to challenge conscious perception and/or to reduce the probability of post-perceptual processing.
Researchers at the LERI together with the AP-HP have developed 2 rapid and inexpensive immunological tests to detect antibiotic resistance. The novelty: the tests detect the activity of bacterial enzymes that hydrolyze extended-spectrum cephalosporins.
A NeuroSpin team succeeded in decoding a large set of human mental processes by training neural networks to predict cognitive labels from a cognitive atlas and by leveraging the data set of NeuroVault, a web-based database for collecting and sharing statistical maps of the human brain.
Radiochemists from the BioMaps unit (SHFJ) have developed and automated the synthesis of an 18F-fluoropyridine containing a thiol function (-SH), allowing its conjugation to model biomolecules within 45 minutes. A step towards rapid radiolabeling of complex biological molecules for PET imaging.
SIMoS team, in collaboration with Bicêtre Hospital, shows that certolizumab pegol, a pegylated monoclonal antibody fragment for anti-inflammatory use, is less likely to trigger an adverse immune response than the non-pegylated form.
Researchers from ICMMO* and ISMO**, in collaboration with a team from I2BC, show that the urea-decorated iron porphyrin catalysts they developed previously for the electro-catalysis of CO2, can be successfully employed in a photo-catalytic approach.
A collaborative study involving an I2BC team unveils the mechanism of autoinhibition of the human flippase ATP8B1, as well as its regulation by lipids and phosphorylation. The study provides a better understanding of the impact of flippase mutations responsible for intrahepatic cholestasis on its enzymatic activity.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.