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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
Researchers from NeuroSpin (Frédéric Joliot Institute/CEA) and MIRCen (François Jacob Institute/CEA Institute of Biology) have just developed an ultrasound device guided by magnetic resonance imaging (MRI) to increase temporarily and locally the vascular permeability in non-human primates, which could be used to effectively deliver drugs to the brain.
In collaboration with a German Research Team from Marburg University, Pavel Müller and Klaus Brettel (I2BC @ Saclay / SB2SM) have studied the first steps of photoactivation of a Class II photolyase of the Methanosarcina mazei archaeobacteria by resolute optical spectroscopy time and discovered a peculiarity of this class of photolyases: photoinduced separation of charges is stabilized by a water cluster, a structural element also preserved in class II photolyases of plants and animals.
According to a study published in the Journal of Nuclear Medicine, Irène Buvat's Research Team (IMIV, SHFJ), in collaboration with the Vincent Frouin's one (UNATI / NeuroSpin) proposed an unprecedented imaging approach based on the use of the ComBat harmonization method derived from genomics. This method correctly estimates the "center" effect that affects the images and thus makes it possible to analyze together radiomic biomarkers of positron emission tomography (PET) images from different centers.
Julie Soutourina (I2BC@Saclay / SBIGeM) was invited by Nature Reviews Molecular Cell Biology to publish a review on the molecular functioning of the Mediator, a multi-protein complex, conserved from yeast to humans, and essential to the regulation of the expression of genes. Potential therapeutic approaches targeting the Mediator (cancer, fungal infections) are also adressed.
A SIMOPRO Research Team, in collaboration with a SCBM Team, has identified, by screening a library of small chemical molecules, a compound capable of reducing the sensitivity of cells to a plant toxin, that is ricin. By collaborating with seven Teams of microbiologists, researchers have shown that this compound, called ABMA, protects cells by blocking an intracellular transport pathway borrowed by many other bacterial and intracellular pathogenic toxins. ABMA defines a new family of broad-spectrum anti-infective agents.
Named Chairman of the Scientific Council of National Education by Minister Jean-Michel Blanquer, Stanislas Dehaene (Inserm / CEA-NeuroSpin / Paris-Sud University/ College de France) will coordinate the work and reflections of the council on learning to feed reflection about strategies to promote student learning. The constitution of the Scientific Council, composed of twenty-one members, was presented on the 10th of January 2018.
The Institute for Integrative Biology of the Cell - I2BC (including Teams from I2BC@Saclay) celebrated the laying of the foundation stone of its future building on the 13th of December 2017 on the CNRS campus in Gif-sur-Yvette. The objective of the I2BC real estate project is to bring together, within a common research and training project, Research Teams in a single location to stimulate interactions, share the most effective skills and equipment.
A patented Radio Frequency (RF) transmission method developed by NeuroSpin for 7 Tesla human brain imaging now removes artifacts still present in 3 Tesla large organ images. This has been demonstrated by UNIRS Research Team in collaboration with Henri-Mondor Hospital in liver imaging. The applied method, called "kT points", substantially improves the quality of images obtained, compared to the conventional method of parallel transmission.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.