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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine.
NeuroSpin researchers used ultra-high-field functional magnetic resonance imaging (7T) to understand how our brains process visual informations in the perception of numbers. Results, published in the journal eLife, show a direct perception of numbers in healthy adults.
168 participants from 21 countries attented the 2019 International Conference on Magnetic Resonance Microscopy (ICMRM) that took place from 18-22 August in Paris. It was co-organized by Luisa Ciobanu (NeuroSpin) and Dimitrios Sakellariou (KU Leuven).
Recent work by SBIGeM (I2BC@Saclay) highlights how two essential components of DNA transcription into RNA coordinate to recruit the Rad2/XPG DNA repair protein, thus linking these two fundamental cellular processes.
The Iseult project magnet being installed at Neurospin (CEA Paris-Saclay) reached a nominal magnetic field of 11.7 teslas (T) on July 18, 2019. This is a world record for a whole-body magnetic resonance imager (MRI) magnet, the culmination of years of R&D, at the forefront of innovation in the field of superconducting magnets.
The SHFJ/IMIV laboratory (Inserm 1023/CNRS/CEA/UP-Sud), in collaboration with hospital-university teams, has shown that, in patients with advanced-stage large cell lymphoma (B type), automatic quantitative measurements of tumor dissemination detected by whole-body PET imaging have a predictive value of progression-free survival (tumor stabilization) and overall survival.
A NeuroSpin team showed that the mere short-term storage of information may proceed without consciousness or persistent neural activity, but that manipulating information in working memory requires both. This study, thereby reconciling a hotly debated topic in the field of neuroscience, was published in PNAS.
A team of NeuroSpin, in collaboration with Hôpital Henri Mondor (Créteil), has developed, by machine learning, a method called SmartPulse, which allows, for large organs, the acquisition of high field (3T) clinical quality images, without prior calibration.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.