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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
The European Research Council (ERC) announced, on December 10, 2019, the winners of the 2019 ERC "Consolidator Grants". Three CEA researchers are rewarded for the excellence of their work in astrophysics, particle physics and chemistry. In Joliot, chemistry is honored with the award of the research grant to Davide Audisio, SCBM, for his expertise in labeling molecules of interest with 14Carbone.
A team from SCBM, in collaboration with Mauritian modelers, has shown that carboxylic acids can be easily converted into small rings with four carbon atoms, the cyclobutanes, using blue LEDs and an iridium catalyst. Cyclobutanes are increasingly used in the design of new drugs and the method described here will help to significantly expand the chemical space explored in "drug discovery".
A team from SIMoS (DMTS) developed, as part of a collaborative study, the first 99mTc-labeled radiotracer specific for an extracellular enzyme, MMP-12, overexpressed in many inflammatory processes, including abdominal aortic aneurysm. This radiotracer, which preferentially marks the aneurysm in an animal model, will be a promising tool for molecular imaging of the various pathologies in which MMP-12 is involved.
A team from SPI, in collaboration with the metabolic biochemistry service and the Institute of Memory and Alzheimer's Disease (IM²A) of the university hospitals Pitié-Salpêtrière, has developed a method for the simultaneous quantification of tau and α-synuclein proteins in human cerebrospinal fluid by high-resolution mass spectrometry. A promising new approach for the differential diagnosis of Lewy bodies dementia and Alzheimer's disease.
A team from I2BC@Saclay, in collaboration with the CNRS (ICMMO, UPSud and ISM2, Aix-Marseille University) has shown that the use of a reversible electron acceptor, able to accept and transfer an electron, in place of a sacrificial electron donor optimizes efficient and clean photocatalysis reactions for the production of organic compounds of interest.
Researchers at BIAM and I2BC@Saclay, in collaboration with Japanese colleagues from Okayama University and Ehime, have characterized in a cyanobacterium a minor protein that diverts part of the energy from photosynthesis to secondary metabolic pathways. This discovery is promising to exploit these metabolic pathways in a biotechnological process of bioenergy production.
Researchers from Pasteur Institute, in collaboration with seven research teams, including SPI (LI2D/Marcoule), developed and evaluated the efficacy of several vaccine candidates against the virus responsible for Lassa haemorrhagic fever, endemic in Western Africa. They identified one of them as being the most effective, likely to quickly enter clinical trials in humans. Results are published in the journal Science Translational Medicine.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.