The laboratory "Normal and Pathological Immune Memory" (LMNP) develops mouse models to study the mechanisms by which CD8 memory precursors are generated and matured into subsets of very functional memory T cells.
This includes the memory cells residing in the tissues, as well as their long-term persistence. The study of molecular signals sequentially emitted by different sub-populations of T-CD4 cells all-along the process of differentiation of T-CD8 memory cells. Studies of mouse models and data from human cohorts are designed to study the mechanisms underlying the generation and maintenance of T-CD8 memory cells in the context of chronic human viral infections and their relationship with viral persistence.