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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Researchers from Pasteur Institute, in collaboration with seven research teams, including SPI (LI2D/Marcoule), developed and evaluated the efficacy of several vaccine candidates against the virus responsible for Lassa haemorrhagic fever, endemic in Western Africa. They identified one of them as being the most effective, likely to quickly enter clinical trials in humans. Results are published in the journal Science Translational Medicine.
A new phylogenetic analysis of the Orange Carotenoid Proteins (OCPs) family, responsible for photoprotection in cyanobacteria, coupled with a functional study, was conducted by a team from I2BC@Saclay. This is the first functional study of the ancestral OCPX which, when compared to OCP1 and OCP2, revealed the molecular determinants that govern the photocycle of these proteins and in particular the fundamental role of the linker connecting the two domains of OCPs.
By studying the self-assembly of a hormone-derived peptide in the presence of lipid membranes, a team of the SB2SM (Joliot Institute / I2BC) in collaboration with the University of Rennes 1 and Ipsen biopharmaceutical group, shows how the interactions electrostatic type modify the structures of the assemblies formed by each of these molecules alone in solution.
A study conducted by Maxime Bertoux (Unit 1171 Inserm / Lille University / CHU Lille) in collaboration with researchers from the Centre Hospitalier Saint Anne, the SHFJ (CEA-Joliot), NeuroSpin (CEA-Joliot) and the ICM shows that the morphological analysis of the cortical sulci would make it possible to recognize Alzheimer's disease in 91% of the cases, against 80% now by anatomical analysis of the cortex.
In collaboration with teams from ENS (Paris) and the University of Marburg, researchers from I2BC@Saclay have elucidated, by optical time-resolved spectroscopy, the complete phooactivation mechanism of a new cryptochrome of the green alga Chlamydomonas reinhardtii, CraCRY.
Researchers from I2BC@Saclay and Iramis, in collaboration with Léon Brillouin laboratory, analyzed the structure of the "corona" of two model proteins adsorbed on silica nanoparticles, by using the small-angle neutron scattering technique. They show that the structures formed are true nano-assemblies, in which the proteins retain their shape.
NeuroSpin's psychiatric researchers and the Inserm U955 unit (CHU Mondor) coordinated, in collaboration with the ENIGMA consortium (an international group of researchers sharing brain imaging data), the first mega-analysis of diffusion MRI data including 3033 subjects with or without bipolar disorders. They identified extensive abnormalities in the cerebral white matter microstructure in sick people. Abnormalities that could represent a robust biomarker of bipolar disorder.
Senescence specialists (SBIGEM), in collaboration with the SCBM and the CNRGH (Jacob Institute), show that glucocorticoids can delay or even short-circuit it and disrupt its function as a tumor suppressor.
By improving the in vitro reconstitution of the iron-sulfur clusters biosynthesis machinery, a team from SBIGEM (CEA-Joliot / I2BC), with its French, German and Spanish collaborators, clarifies the function of frataxin, a protein involved in Friedreich’s ataxia.
A new PET imaging method by antibody pretargeting was developed at SHFJ, in collaboration with teams of SCBM and SPI. It consists in reacting in vivo a molecule labeled with 18Fluor with an antibody previously fixed on a tumor and this, in an extremely fast and selective manner, thanks to a « click-chemistry » reaction. The very good results obtained allow to consider the use of pre-targeted antibodies in nuclear medicine.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.