Presentation
The ISOBIOTICS project, coordinated by Dr. Christophe Dugave at CEA (SCBM/DMTS), aims to develop new approaches for the isotopic labeling of biological drugs such as peptides, proteins, oligonucleotides and analogues, with 2H/3H, 13C/14C and 18F through the training of talented young chemists between 2023 and 2027. Fellows will prepare a PhD in 3 or 4 years (depending on their university of affiliation).
ISOBIOTICS: a new strategy for the isotopic labeling of biological drugs
Recent years have seen the clinical introduction of bio-drugs such as peptides, proteins and oligonucleotides, due to their specificity and low toxicity compared to chemical drugs. Analysis of the pharmacokinetics of these bio-drugs requires the incorporation of radioisotopes to trace their distribution in the body. The radiolabeling of biopharmaceuticals represents a major challenge. However, radiolabeling of biopharmaceuticals represents a major challenge, and in order to reduce their immunogenicity, overcome their fragility and increase their ability to reach their target, it is mainly small-scale biologics that are being developed. The ambition of the ISOBIOTICS project is therefore to develop a new radiolabeling strategy adapted to these particular molecules to i) advance research and development into biotherapies that are more effective in terms of targeting and less immunogenic, and ii) train a new generation of radiochemists with a dual academic and industrial culture who will implement these methods to meet the needs of European industry.
Objectives and ambitions :
- Develop new, chemically harmless strategies for late-stage radiolabeling of large peptides, small to medium-sized proteins, oligonucleotides and analogues with deuterium, tritium, carbon-14 (phase 0 preclinical and clinical evaluation) and fluorine-18 (phase I-III clinical trials).
- Train a new generation of talented young PhD students specializing in radiolabeling of bio-products through a combination of interdisciplinary laboratory research, cross-disciplinary and cross-industry secondments, technical courses, scientific conferences and complementary skills workshops.
- Ensure the appropriate dissemination, exploitation and communication of all ISOBIOTICS results to maximize the project's impact and influence
- Guarantee the employment of students and the sustainability of training structures
Project duration
4 years
|
Funding
2,7 millions €
|
Number of partners
16
|
Starting date
February 01, 2023
|
Coordinator : CEA
Joliot institute contact : Christophe Dugave (christophe.dugave@cea.fr)
COMMUNICATION
- Websites https://www.isobiotics-project.org/ - https://cordis.europa.eu/project/id/101072780
ISOBIOTICS official video
- ISOBIOTICS Newsletter n°1 (summer 2023)
agreement number : 101072780
About Doctoral networks (ex-itn)
Objective of Doctoral
Networks (DN, ex ITN)
Implement doctoral programmes by partnerships of
organisations from different sectors across Europe and beyond to train highly
skilled doctoral candidates, stimulate their creativity, enhance their
innovation capacities and boost their employability in the long-term.
Types of Doctoral Networks
Doctoral Networks implement doctoral programmes, by partnerships of
universities, research institutions and infrastructures, businesses including
SMEs, and other socio-economic actors from different countries across Europe
and beyond. These doctoral programmes will respond to well-identified needs in
various research and innovation areas, expose the researchers to the academic
and non-academic sectors, and offer research training, as well as transferable
skills and competences relevant for innovation and long-term employability. Besides standard Doctoral Networks, incentives have been introduced to promote
two specific types of doctorates as well:
Industrial Doctorates. They train PhD candidates who wish develop
their skills and step outside academia, in particular in industry and business.
Individual participants must be enrolled in a doctoral programme and jointly
supervised by the academic and non-academic partners.
Joint Doctorates. They provide a highly integrated type of
international, inter-sectoral and interdisciplinary collaboration in doctoral
training leading to a joint doctoral degree or multiple doctoral degrees
awarded by the participating institutions. PhD candidates must be enrolled in a
joint programme and be jointly supervised.