Genopole held its first D4GEN Hackathon on 19–21 May 2022 with the goal of creating interdisciplinary, computational genomics communities aimed particularly at the sharing, preservation and (re)use of genomics Big Data. During the event, held at the Telecom Paris Sud campus, a number of teams worked to imagine and develop innovative problem-solving solutions in four topics. Jérôme Arnoux, PhD student at LABGeM (Genoscope), led the team that took home the third-place prize from that competition.