MIRCen's radiochemistry platform allows the development and the production of new radiotracers labeled with positron emitters. These very sensitive molecules are at the basis for PET imaging.
The IBA Cyclone 18/18 cyclotron enables the production of two short half-life radioisotopes, the carbon-11 and the fluor-18 (respectively 20.4 et 109.8 min), in the form of [11C]CO2 and [18F]fluoride. In the near future, a third radioisotope will be produced, the zirconium-89. Its half-life of 3.3 days is well suited for imaging macromolecules such as antibodies.
IBA Cyclone 18/18 cyclotron*
Activities
Carbon-11 labeling: 11C-methylation from [11C]MeI and [11C]MeOTf production of [11C]CO and of [11C]HCN, 11C-carbonylations, 11C-cyanations,11C-catalyses au Pd, Rh, Se et Ni, aryl et alkyl-11C-methylations photocatalyzed (using the method of Pipal et al, 589 (7843), 542-547, Nature 2021)...
Complex multistep syntheses, e.g. the ligand for D2/D3 receptors, the (+)[11C]PHNO (Plisson et al, 70, 380-387, Appl Radiat Isot 2012).
Fluor-18 labeling: direct aromatic or aliphatic nucleophilic 18F-fluorination, indirect markings of macromolecules (synthesis of a prosthetic group followed by coupling of the group with the macromolecule under mild reaction conditions). It is also possible to use « Click » chemistry methods.
Complex multistep syntheses are possible with 4 possibilities of pre-purification, 2 radio-HPLC and 2 reformulation systems of the automat.
Example
of a labeling using 2 reactors and 2 HPLC : synthesis and purification of
2-[18F]fluoroethyl tosylate followed by the S-18F-fluoroethylation
of a thiophosphate (Vries et al, 58, 469-476, Appl Radiat Isot 2003)
Example
of a labeling using 2 reactors and 2 HPLC : synthesis and purification of
2-[18F]fluoroethyl tosylate followed by the S-18F-fluoroethylation
of a thiophosphate (Vries et al, 58, 469-476, Appl Radiat Isot 2003)
Principal equipments
Hot cells, Lemer
Pax*
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Automated synthesis system, MeIplus Research, Synthra
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MeIplus Research synoptic
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Automated synthesis
system, FlexLab, iPhase
| FlexLab synoptic
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* crédit photos : L.Godart/CEA