The LREG is a group belonging to the GIS Team, comprised of three scientists and four technicians. During 2015, they hosted a doctoral student (Michaël Baco) and a postdoctoral scholar (Fany Blanc).
RESEARCH PROJECTS
The LREG maintains a cutaneous melanoma porcine model (MeLiM model) in which tumors appear in utero or rapidly after birth, causing metastases that regress spontaneously during the first year of life of the piglets. This regression is accompanied by a loss of pigmentation of the hair coat and vitiligo. The group develops studies aimed at the genetic susceptibility of the development of cutaneous melanoma in this porcine experimental model along with mechanisms inducing a spontaneous tumor regression.
Genome Wide Association Studies (GWAS) and functional studies of gene candidates are carried forth on MeLiM porcine families in order to identify what genes are implicated in the oncogenesis of porcine melanoma.
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Tumeur cutanée après régression et vitiligo
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| In parallel, comparative genetic studies are performed using the results obtained by partners from human families developing melanomas (in partnership with F. Demenais’ team, INSERM, Paris) and in dog breeds that are carriers for cutaneous melanoma (in partnership with C. André’s team, CNRS, Rennes). In order to understand the cellular and molecular mechanisms implicated in the induction of tumor regression, studies are performed on the tumor (transcriptomics analysis: RNA and microRNA) and on the antitumoral immune response of the host (phentoyping of immune cells, search for antibodies and functional tests).
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All the studies are led in partnership with other scientists from the UMR GABI, the INRA Jouy en Josas research center (Virology and Immunology), national partners (INSERM, CNRS) or international partners (Czech Republic, Spain, Taiwan).