​ ​​Our group, team of Laboratory of Molecular Hematopoiesis (LHM), investigates molecular mechanisms controlling gene expression, with strong emphasis on long-range genomic interactions, and associated pathological disorders in erythroid cells. The major goal of the laboratory of molecular hematopoiesis is to understand how genes are controlled in time and space during dynamic processes such as cellular differentiation and development. We use hematopoiesis, and specifically eythropoiesis, as a biological system to dissect the molecular events leading to fine tuning of gene expression.

​  ​ Dr Eric SOLER Principal investigator Phone : +33 (0)1 46 54 89 39 eric.soler@cea.fr     Secretary of UMR 967 ​Aurélie GOURET Phone : +33 (0)1 46 54 98 66 aurelie.gouret@cea.fr   Arielle LELIARD Phone : +33 (0)1 46 54 99 49 arielle.​leliard@cea.fr​​

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We focus our attention on the LDB1 transcription factor complex, a major regulator of erythroid differentiation, allowing control of gene expression over long genomic distances (from several kb up to 1 Mb) through the establishment of chromatin loops connecting distal enhancers with their target genes. These types of long-range interactions are critical in gene regulatory networks and may be affected in several diseases. We recently showed that long-range enhancer-gene interactions at the HBS1L-MYB locus are affected by genomic variants, resulting in modulation of disease severity in beta-thalassemia patients, underscoring the need to decipher such long-range interactions across the genome and to understand their impacts on gene expression. ​ 

• we aim to unravel the molecular determinants of following erythroid disorders  :
• beta thalassemias and sickle cell anemia.
• ​lacute erythroid leukemias.
• provide a functional annotation of the genome.
• identify novel therapeutic targets​.
• characterize genotype/phenotype relationships in humans. 

To this aim we use a set of complementary approaches ranging from high throughput chromatin profiling to spatial organization of chromosomes (ChIP-Seq, RNA-Seq, 3C-Seq), combined with proteomic analyses of transcription factors in order to identify novel regulators and to decipher molecular mechanisms of erythroid differentiation.