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Fundamental Research Division
The DRF at the CEA assemble approximately 6,000 scientists since January 2016.
Non-coding regions of the genome appear to reduce the severity of two red blood cell diseases: beta thalassemias and sickle cell anemia. Researchers at the CEA-IRCM, in collaboration with English and Dutch laboratories, have elucidated mechanisms explaining how non-coding DNA sequences exert their action to improve symptoms of these two diseases.
A new type of giant virus, dubbed “Pithovirus”, was discovered in the frozen soil of extreme northeast Siberia by researchers from the CNRS/Aix-Marseille Université, CEA-IRTVS, CEA-IG and the Russian Academy of Sciences. Buried in the ground, this giant virus has survived more than 30,000 years of freezing.
A European consortium, of which the CEA-IMETI is a member, has developed a vaccine against the Chikungunya virus and tested it in a rodent model. Trials in humans could begin in 2015.
A study conducted by an international team, notably involving researchers from the CEA-IG (Genoscope), provides first-time evidence that measurable heritability may be based on epigenetic variations and not necessarily on variations in the DNA sequence.
The mass extinction of large animals during the last ice age is due to the climate, but what are the specific reasons for this? A collaboration involving 30 teams from 12 countries, including the CEA-IG, has provided some answers by sequencing free DNA taken from the Arctic permafrost.
The protein LEAFY plays an essential role in the beauty of the plant world, as it governs the formation of flowers. As part of an international collaboration, a joint team including the CEA-IRTSV has managed to trace its history and to elucidate the evolutionary mechanism that gave it the ability to direct floral morphogenesis.
An Anglo-French team (AP-HP, Inserm, CEA/Mircen, UPEC, Oxford Biomedica, Cambridge University) coordinated by Professor Stéphane Palfi (head of the neurosurgery department at the hôpital Henri-Mondor) conducted a gene therapy trial in 15 patients with an advanced form of Parkinson’s disease.
How can new therapeutic strategies for antibiotic-resistant bacteria be found? A team from the IBS is developing a means for investigation through the in vitro fabrication of the Pneumococcus wall. This is a method with which to develop and test new antibiotics.
400 exomes were sequenced by the CEA-IG-CNG through a partnership with the Fondation maladies rares.
Experiments in yeast to understand the causes of mental disability? As amazing as this may sound, researchers from the CEA-IRTSV have used this model to explain the molecular origin of certain defects in the human cortex. These results are published in the journal Nature Genetics.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.