How does it work?
CEA-Leti's Suspended Micro Resonator is a micrometric silicon beam that vibrates at several hundred kHz. This beam incorporates a microfluidic channel through which a fluid flows. When a cell passes through, the beam vibrates at a
frequency proportional to the cell's mass.
By comparing the masses of treated and untreated tumor cells, the SMR can reveal a change in mass, which can in turn illustrate a treatment's effectiveness.
Advantages?
The most appropriate treatment for a patient is identified within 48 hours of sample collection from a panel of 20 FDA-approved drugs. Administering the most effective anti-cancer treatment as quickly as possible is decisive for the outcome of the disease.
This suspended micro-resonator opens up new perspectives in personalized medicine. No other technique measures such small masses (femtogram, or even attogram).
Our research areas:
- Optimization of manufacturing process steps
- Increased miniaturization of components
- Improving substrate sealing (silicon, SOI, glass)
- Micro-resonator geometry and architecture
Applications?
Evaluation of chemotherapies, targeted therapies and immunotherapies in personalized medicine for cancer treatment.