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AirCheck

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Published on 13 November 2023





​AirCheck​​​

A portable and automated system for collecting and identifying bioaerosols using biomolecular amplification​

AirCheck can detect pathogenic microorganisms in the air. It consists of an airborne sampling module for bioaerosols and a microfluidic analysis system.

Thanks to CEA-Leti's design, it is:​ 

  • Fast: analysis results in less than 30 minutes​
  • Portable: weighs less than 1 kg, useable for analysis in the field​​
  • Modular: multiplexing enables the simultaneous identification of several targets/strains (viruses, bacteria, etc.)​
  • Simple: automation makes the system accessible and easy to use​​
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​​How does it works?​
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Aerosols are collected using electrostatic precipitation (Corona effect) at a flow rate of 5 to 15 l/min. As the sample is eluted by a microfluidic device in less than 100 μl, it is nearly 150 to 200 times less diluted than in current systems. Detection is carried out by isothermal biomolecular amplification (LAMP). The microfluidic chip can be equipped with several specific detection chambers containing lyophilized primers for multiplexing/multi-targeting.​

​​What's new?

​​An automatic 3-in-1 workflow: Without any manual steps, the system automatically collects and prepares a sample for target pathogen identification in just a few minutes. Compact and lightweight, it enables remote analysis while guaranteeing laboratory-grade analytical performances.​​​



 What's next?
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CEA-Leti teams will be expanding its analytical capabilities:​
  • Targets (yeasts, spores, mycotoxins, etc.): developments of new sample preparation steps (lysis, grinding, etc.)
  • Multiplexing
  • Automation for successive analyses​
The aim is also to improve the card’s recyclability/reusability thanks to the regeneration of the bio-sampling membrane.
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​​Applications

The AirCheck project is part of the "One Health" approach and designed to address:​

  • Animal health: By enabling the detection of viruses and bacteria in livestock, it could help reduce the use of antibiotics and assist in decision-making for vaccination, isolation or slaughter.
  • ​​Human health: Developed in response to the Covid-19 pandemic, this instrument is suitable for non-invasive human screening in civilian and military sectors (detection of biological threats).​​

Key facts
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  • Efficient: 90% collection efficiency over the 10 nm to 1 μm range at 6 l/min
  • Quiet: Thanks to the absence of a pump, it is silent and requires little energy (≤ 23 dB).​​

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