​Edited by E. Pebay-Peyroula, H. Nury, F. Parcy, R.W.H. Ruigrok, C. Ziegler, L.F. Cugliandolo Oxford University Press ISBN: 978-0-19-875295-0 2016, 464 pages From Molecules to Living Organisms: An Interplay Between Biology and Physics: Lecture Notes of the Les Houches School of Physics: Volume 102, July 2014 (Lecture Notes of the Les Houches Summer School)

The book gathers lecture notes of courses given at the 2014 summer school on integrated biology in Les Houches, France, Session CII. It addresses an emerging field ranging from molecules to cells and to organisms. Through examples it presents a new way of thinking using a combination of interdisciplinary and cutting-edge methods, bridging physics and biology beyond current biophysics. Important novel developments are expected in the coming years that may well introduce paradigm shifts in biological science. The school had the ambition to prepare participants to become major actors in these breakthroughs.

Part I: Concepts in cell biology and examples of multiscale studies in biology

1 - Franz Bruckert: Introduction to cell biology

2 - Nikolas Herold, Hans-Georg Kräusslich, Barbara Müller: A small leak will sink a great ship: HIV-host interactions

3 - Icham Chahtane, Grégoire Denay, Julia Engelhorn, Marie Monniaux, Edwige Moyroud, Fanny Moreau, Cristel Carles, Gabrielle Tichtinsky, Chloe Zubieta, François Parcy: Flower development: An integrated view

Part II: Concepts in Physics and emerging methods

4 - Guiseppe Zaccai: Thermodynamics (a reminder)

5 - Enrico Luchinat: NMR spectroscopy, from basic concepts to advanced methods

6 - Albert Guskov, Dirk Jan Slotboom: SEC-MALLS to determine protein oligomeric states

Part III: Plant development: From genes to growth

7 - George Coupland: Mechanisms controlling time measurement in plants and their significance in natural populations

8 - Oliver Hamant: Forces in plant development

9 - Christophe Godin: Virtual plants

Part IV: Forces in Biology: Reshaping membranes

10 - Patricia Bassereau, Winfried Weissenhorn, Michael Kozlov: Membrane remodeling: Theoretical principles, structures of protein scaffolds and forces involved

Part V: Conformational changes and their implications in diseases

11 - Yves Gaudin: Protein conformational changes

Part VI: Membrane transporters: F​​rom structure to function

12 - Christine Ziegler: The do's and don'ts in handling membrane proteins for structural studies

13 - François Dehez: Molecular simulation: A virtual microscope in the toolbox of integrated structural biology