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Structural and functional analysis of Bunyavirales replication and transcription

Vendredi 17 septembre 2021 à 14:00, Visioconférence

Publié le 17 septembre 2021
Benoît Arragain
Institut de Biologie Structurale, Institut de Recherche Interdisciplinaire de Grenoble
Many viruses are public health threats. The Bunyavirales order includes several important and/or emerging human pathogens that cause hemorrhagic fevers, such as Hantaan virus, or encephalitis, such as La Crosse virus. Bunyavirales also show similarities with influenza viruses, an infectious agent responsible for seasonal epidemics. Although vaccines against influenza are available, there is currently no treatment against Bunyavirales infection, which is why understanding the functioning mechanisms of these viruses is fundamentally important. This thesis focuses on the structural and functional analysis of two major viral players responsible for the multiplication of the viral genome and viral proteins within an infected cell: nucleocapsids, which protect the viral genetic information, and viral polymerases, which allow to replicate and transcribe the viral genome.


Pour suivre la soutenance en visioconférence : https://univ-grenoble-alpes-fr.zoom.us/j/96958160210?pwd=eVMrcmE0UXNoc09UcmMxdjBkYnA5QT09

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