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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Mapping the human "connectome" requires identifying the anatomical connections made by the white fibers. A NeuroSpin researcher (GIN / Bordeaux) participated in a large study involving 20 research teams, with the aim of providing the best possible reconstruction of anatomical connectivity of the human brain with tractography procedures. The results of this study, published in Nature Communications, show the limitations of tractography and should favor the development of new algorithms.
A SPI/LERI Research Team has recently developed new test strips for the detection of some multi-resistant bacteria. A hospitalization project for these high-speed screening tests will be rolled out in 2018 with funding from EIT Health.
In a recent review published in Science, Stanislas Dehaene (director of NeuroSpin, Inserm-CEA-University Paris-Saclay) and his colleagues suggest that the word "consciousness" includes two different types of information processing calculations in the brain: C1, which integrates the information and makes it available, and C2, which is the reflexive process. Do machines have a conscience?
The Frédéric Joliot Institute (and in particular the SPI / LERI), a Research Team from the Bicêtre Hospital APHP— Paris-Sud University and NG Biotech have developed new rapid tests to detect certain forms of antimicrobial resistance in hospitals.
In a study conducted by the Neurofunctional Imaging Group (GIN, NeuroSpin, Bordeaux), a classification technique by Support Vector Machine (SVM) , a supervised learning technique, is used to predict the different hemispheric dominance patterns for language and to highlight the existence of very rare patterns in some healthy individuals.
A Research Team from the SHFJ (IMIV) highlights, through a preclinical model of exposure to alcohol, an immediate and persistent neuro-immune response, several months after the initial exposure of alcohol. These results confirm the occurrence of brain damage that may play a key role in the neurological deficits reported in teenagers who like "binge-drinking", that is to say an excessive consumption of alcohol over a very short time.
A Research Team of the SCBM (Frédéric Joliot Institute), in collaboration with the SIMOPRO (Frédéric Joliot Institute), Strasbourg University and the start-up Syndivia, has just discovered a new chemical reaction allowing both to bind and to cleave molecules in biological media ("click and release" reaction).
An LSOD Research Team (I2BC@Saclay), in collaboration with a Research Team from Mar del Plata University (Argentina), has been able to characterize for the first time a NO-Synthase of plants. Researchers have shown that NO-Synthase from Ostreococcus tauri (pico plankton from the Thau lagoon) produces very large amounts of NO compared to human NO-synthases. However, terrestrial plants do not have NO-synthases and the biological role of this enzyme remains unknown.
For the first time, an animal model expresses the two biological characteristics of Alzheimer's disease. Researchers from MIRCen (François Jacob Institute), SPI (LEMM), Inserm, Universities Paris-Sud and Paris-Descartes and CNRS have developed an animal model that reproduces the progression of the human disease.
Two Research Teams led by Odette Prat of the Institute of Biosciences and Biotechnologies (BIAM) and Jean Armengaud of the Frédéric Joliot Institute (LI2D, Marcoule) have joined forces thanks to an ANR funding to deepen knowledge of the importance of the nature of protein crowns on the cellular impact of nanoparticles. The results from their three recent publications reveal a new concept: "the protein interactome applied to the corona of nanoparticles".
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.