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To carry out their activities, Research Teams of the Frédéric Joliot Institute for Life Sciences have developed high-profile technological platforms in many areas : biomedical imaging, structural biology, metabolomics, High-Throughput screening, level 3 microbiological safety laboratory...
All the news of the Institute of life sciences Frédéric Joliot
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Being part of an international consortium, the Neurofunctional Imaging Group (NeuroSpin, Bordeaux) and the Max Planck Institute for Psycholinguinstics have characterized the asymmetries of surface and thickness of the cerebral cortex of 17,141 individuals from MRI. This study published in PNAS, the largest ever done, provides a unique reference for studying the genetic basis of cerebral asymmetries and the alteration of lateralization during cognitive, neurological and psychiatric disorders.
A team from I2BC@Saclay (SB2SM), in collaboration with the RPBS platform, has put online a server for structural prediction of interactions between proteins. This server, designed for biologists, uses the information provided by the coevolution of protein sequences and predicts the structure of protein complexes, essential information for understanding their functional role.
NeuroSpin researchers (UNATI and UNICOG), in collaboration with the Timone Neuroscience Institute, have studied a type of individual anatomical variation in the structure of the human cortex, the transverse gyrus or 'fold crossing', which separates grooves in two parts. They showed that the presence of this structure in the upper temporal groove is heritable. This result is important, given the role of this region of the brain in the production of language.
Two Research Teams from I2BC@Saclay and SPI (LI2D, Marcoule), in collaboration with IRAMIS, highlight the very strong affinity of silica nanoparticles for proteins with RGG motifs (family of binding proteins). RNA), especially when these are methylated. These results are important for the development of safe by design approaches.
The SHFJ LDM-PET team (GIP Cyceron, Caen), in collaboration with the University Hospital of Caen, successfully used, for the first time in the clinic, the radiopharmaceutical drug developed and produced by the researchers of the team. , the [18F] Fludarabine. This drug, which is innovative for lymphoproliferative diseases, has been shown to be more effective in terms of specificity and sensitivity than its current counterpart, [18F] FDG.
Collaborative work between the SBIGeM (I2BC@Saclay) and the Marseille Cancer Research Center, published in Molecular Cell, illuminates the mechanistic basis and genetic control of homologous recombination, a mechanism for repairing DNA breaks responsible for chromosome exchange during meiosis. However, canonical models do not explain the complexity of meiotic recombination profiles and this study, which reconstructs reaction intermediates, constitutes a major advance in the understanding of this mechanism.
In a study published in Analytical Chemistry, the Mass Spectrometry Research Team of the Laboratory Drug Metabolism Research Laboratory (SPI) demonstrated the interest of Orbitrap Fusion, a state-of-the-art mass spectrometer for the identification of relevant metabolites based on their masses and isotopes measured with high accuracy.
As part of a collaboration with MIRCen (Institute of Biology François Jacob) and SBIGeM, SCBM researchers have developed functional micellar nanovectors capable of targeting a population of cancer cells.
Why are we aware of certain visual stimuli and not others? An international study, involving Stanislas Dehaene's group from NeuroSpin, provides answers.
Cell biology uses fluorescent labeling, an essential technique to follow the life of the cell. But fluorescent proteins have their limits, which researchers from IBS and I2BC @ Saclay (SB2SM) are trying to repel.
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CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.