Edited by Jean-Jacques Feige, Gilles Pagès and Fabrice Soncin
Research Signpost
ISBN: 978-2-8178-0466-8
2007, 230 pages
Molecular mechanisms of angiogenesis: From ontogenesis to oncogenesis. | | 
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Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological situations including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells,…) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable bloodproof neovessels.
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Chapter 1
Emergence of endothelial cells during vascular development
Eichmann et al.
Pages 3-23
Chapter 2
Lymphatic vascular morphogenesis
Tatin F et al.
Pages 25-44
Chapter 3
Finding new partnerships: The function of individual extracellular receptor domains in angiogenic signalling by VEGF receptors
Hyde Caroline AC et al.
Pages 47-75
Chapter 4
Wnt/Frizzled signaling in the vasculature
Couffinhal T et al.
Pages 77-97
Chapter 5
BMP9, BMP10, and ALK1: An emerging vascular signaling pathway with therapeutic applications
Bailly S
Pages 99-119
Chapter 6
Apelin signaling in retinal angiogenesis
Audigier Y et al.
Pages 121-148
Chapter 7
Emerging role of the two related basic helix-loop-helix proteins TAL1 and LYL1 in angiogenesis
Pinet V et al.
Pages 149-167
Chapter 8
Hypoxia and extracellular matrix remodeling
Muller L et al.
Pages 171-197
Chapter 9
Sphingosine-1-Phosphate in hypoxic signaling
Cuvillier O
Pages 199-217
Chapter 10
Reciprocal crosstalk between angiogenesis and metabolism
Laurent G et al.
Pages 219-233
Chapter 11
Endothelial progenitor cells and cardiovascular ischemic diseases: Characterization, functions, and potential clinical applications
Smadja D M. et al.
Pages 235-264
Chapter 12
Endothelial cell reactions to oxygen: Implications for cancer
Oliveira RL et al.
Pages 267-282
Chapter 13
Tumor angiogenesis and lymphangiogenesis: Microenvironmental soil for tumor progression and metastatic dissemination
Paupert J et al.
Pages 283-306
Chapter 14
Angiogenesis and Invasion in Malignant Glioma: Friends or Foes?
Daubon T et al.
Pages 307-324
Chapter 15
Role of endothelial cells in tumor escape from immunity
Soncin F
Pages 325-337
Chapter 16
Tumor high endothelial venules and lymphocyte trafficking
Veerman KM et al.
Pages 339-352
Chapter 17
Posttranscriptional regulation of angiogenesis through AU-rich mRNA degradation: potential application in cancer therapy
Planel S et al.
Pages 353-372
Chapter 18
Antiangiogenic drugs in cancer therapy: Effect on advanced renal cell carcinoma
Négrier S
Pages 375-382
Chapter 19
Anti-angiogenic therapies in colorectal cancer
Eveno C et al.
Pages 383-396
Chapter 20
Resistance to antiangiogenic treatments via upregulation of substitution pathways
Grépin R et al.
Pages 397-419
Chapter 21
VEGF-A splice variants: Do they play a role in tumor responses to Anti-angiogenic therapies?
Eymin B et al.
Pages 421-442
Chapter 22
Progenitor endothelial cells as biomarkers of Anti-vascular agents
Taylor M et al.
Pages 445-460
Chapter 23
Soluble Vascular Endothelial (VE)-Cadherin: Toward a marker of endothelial dysfunction
Sidibé A et al.
Pages 461-478
Chapter 24
The prognostic and predictive value of VEGF across various tumor types
Pallaud C
Pages 479-492