SBCF 2024 Thesis Prize to Adrian Candelas

Each year, the Société de Biologie Cellulaire de France (SBCF) awards a thesis prize for outstanding work contributing to a significant advance in the field of cell biology.

This year’s SBCF 2024 thesis prize was awarded to Adrian Candelas for his work entitled “Role of Bone Marrow Stromal Cells in the Polarization and Division of Human Hematopoietic Stem and Progenitor Cells”.

Published on 14 December 2024

Adrian Candelas completed his thesis under the supervision of Stéphane Brunet and Manuel Thery in the CytoMorphoLab laboratory (IRIG/LPCV) at Hôpital Saint Louis Paris/IPGG Institut Pierre-Gilles de Gennes Paris/CEA Grenoble. His thesis work was based on the development and use of an original experimental system of “minimalist artificial niches”. This work allowed him to demonstrate that human haematopoietic stem cells and progenitors have the capacity to interact with different stromal cells in niches mediated by the CXCR4-CXCL12 signaling pathway which induces cytoskeleton remodeling and eventually cell polarization. These heterotypic interactions promote asymmetric cell division and the production of daughter cells that differ in their differentiation potential. These new findings shed light on how haematopoietic stem cell divisions are spatially regulated within micro-niches, and how they contribute to the plasticity of early haematopoiesis.

Top page

Keywords : PCV | hematopoiesis | cytoskeleton

Alternative and Atomic Energies Agency

CEA is a French government-funded technological research organisation in four main areas: low-carbon energies, defense and security, information technologies and health technologies. A prominent player in the European Research Area, it is involved in setting up collaborative projects with many partners around the world.

Interdisciplinary Research Institute of Grenoble (IRIG)

In the same section :

SBCF 2024 Thesis Prize to Adrian Candelas

Keywords : PCV | hematopoiesis | cytoskeleton

Browse the site

Alternative and Atomic Energies Agency

Browse the portal

Interdisciplinary Research Institute of Grenoble (IRIG)

Interdisciplinary Research Institute of Grenoble

Departments of the institute

Laboratories at the Institute

Platform and technical facilities at our Institute

Scientific results of the laboratories

Scientific production of the institute

In the same section :

SBCF 2024 Thesis Prize to Adrian Candelas

Keywords : PCV | hematopoiesis | cytoskeleton

Browse the site

Alternative and Atomic Energies Agency

Browse the portal